Lives listing by nationality: English
- Smith, William (born 1769–died 1839), English geologist, civil engineer, civil servant
- Smithsby, Rabsy (born before 1660), English gentlewoman
- Smyth, James Carmichael (born 1742–died 1821), English physician
- Smythe Owen, Edward William [née Pemberton] (born 1793–died 1863), English [unknown occupation]
- Snape, Reverend Doctor Andrew (born 1675–died 1742), English university administrator
- Snow, John (flourished 1713–1716), English politician
- Snow, Matthew (flourished c. 1724), English lawyer
- Snow, Thomas (flourished 1712–1713), English goldsmith, banker
- Society of Antiquaries (founded 1707), English academy, learned society, antiquarian society
- Society for the Encouragement of Arts, Manufactures and Commerce (founded 1754), English academy, learned society
- Society for the Propagation of the Gospel (founded 1701), English missionary organization
- Socket, Mrs — (flourished c. 1792), English home-maker
- Somers, John, 1st Baron Somers (born 1651–died 1716), English lawyer, politician, member of Parliament, civil servant, academician
- Princess Sophia Matilda, of Gloucester (born 1773–died 1844), English aristocrat
- South, Sir James (born 1785–died 1867), English astronomer, scientist
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